Abrahams Shameemah, et al.
Neuroscience, 2019
Abstract
The global burden of neurodegenerative disorders has increased substantially over the past 2 decades due to rising rates of population aging. Although neurodegenerative disorders differ in their clinical presentation, the underlying pathobiological processes are largely shared. Oxidative stress, among other mechanisms, is strongly implicated in neurodegenerative disorders and aging, and can potentially be targeted by antioxidative agents. Curcumin, a component of turmeric, is a compound that has received considerable attention for its therapeutic properties, and it is considered to be a powerful antioxidant. In this review, we analyzed the evidence for curcumin as an antioxidant in models of neurodegenerative disorders as well as oxido-nitrosative stress. A total of 1451 articles were found from 3 scientific literature databases (PubMed, Scopus, and Web of Science). After all exclusions, a final total of 64 articles were included in this review. The majority of the studies showed that curcumin, or derivatives thereof, were protective against oxidative and/or nitrosative stress in various cellular and animal models. Overall, curcumin protected against lipid and protein oxidation with a reduction in levels of malondialdehyde, and protein carbonyls, thiols and nitrotyrosines. Furthermore, it stimulated the activities of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase. In conclusion, curcumin appears to be a promising compound for phytomedicine. However, due to some concerns about its efficacy, further targeted experiments are needed to identify its exact molecular targets and pathways responsible for its antioxidant effects.
Keywords
antioxidant; curcumin; curcumin derivatives; neurodegenerative disorders; nitrosative stress; oxidative stress.
Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
| PMID: | 30825584 |
|---|---|
| DOI: | 10.1016/j.neuroscience.2019.02.020 |
| Category: | Antioxidants |
The best supplements with Curcumin in Antioxidants category:
- Inflame-X, Advanced Inflammatory Response Support, 120 Vegetable Capsules (Zahler) - Zahler's Inflame-X contains a combination of herbs and nutrients that help to support health inflammatory response function after strenuous exercise. It contains among others: Curcumin.
- Turmeric Supreme, Extra Strength, 120 Vegan Liquid Phyto-Caps (Gaia Herbs) - Helps reduce occasional inflammation due to normal daily wear & tear. It contains among others: Curcumin.
- Turmeric, 90 Vegetarian Capsules (Paradise Herbs) - Paradise products have won 10 Best of Supplements Awards. It contains among others: Curcumin.
- Turmeric & Bromelain, 90 Veg Capsules (Now Foods) - NOW Turmeric & Bromelain is a botanical combination created to support healthy joint tissue. It contains among others: Curcumin.
- Curcumin, 60 Veg Capsules (Now Foods) - Curcumin is the major bioactive component found in the roots of Turmeric (Curcuma longa), a plant belonging to the ginger family. It contains among others: Curcumin.
- Curcumin, 120 Veg Capsules (Now Foods) - Curcumin is the major bioactive component found in the roots of Turmeric (Curcuma longa), a plant belonging to the ginger family. It contains among others: Curcumin.
- CurcuBrain, Cognitive Support, 400 mg, 50 Veg Capsules (Now Foods) - Curcumin is a powerful free radical neutralizer that is known to support balanced immune function, but is also known to have poor bioavailability. It contains among others: Curcumin.
Articles similar to "Antioxidant Effects of Curcumin in Models of Neurodegeneration, Aging, Oxidative and Nitrosative Stress: A Review."
- The role of Curcumin in Antioxidants: Curcumin, an Active Component of Turmeric (Curcuma Longa), and Its Effects on Health. (Turmeric (Curcuma longa) is a type of herb belonging to ginger family, which is widely grown in southern and south western tropical Asia region...)
Previous article
Curcumin, an Active Component of Turmeric (Curcuma Longa), and Its Effects on Health.