Pilot Feasibility and Safety Study Examining the Effect of Medium Chain Triglyceride Supplementation in Subjects With Mild Cognitive Impairment: A Randomized Controlled Trial.

Rebello Candida J., et al.
BBA clinical, 2015

Abstract

Background

Impaired brain glucose metabolism appears to be a potential pathogenic feature of mild cognitive impairment (MCI). This study examined the potential for increasing circulating ketone bodies through medium chain triglyceride (MCT) supplementation, as a means to beneficially modulate brain homeostasis in subjects with MCI.

Methods

Six participants with MCI were enrolled in a randomized placebo-controlled trial. Participants received 56 g/day of either medium chain triglycerides (MCTs) or placebo for 24 weeks. Serum β-hydroxybutyrate concentrations, apolipoprotein-E4 status, and cognitive assessments were carried out. Due to the small number of participants only the raw scores were examined.

Results

Intake of MCT oil increased serum ketone bodies and improved memory, while intake of placebo did not show improvement in any of the cognitive measures tested.

Conclusions

Consumption of 56 g/day of MCTs for 24 weeks increases serum ketone concentrations and appears to be a candidate for larger randomized control trials in the future that quantify the modulation of cognitive function through supplementation with ketone precursors, in patients with MCI.

Keywords

Alzheimer's disease; Ketone bodies; Medium chain triglycerides; Memory; Mild cognitive impairment.

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• The role of Medium-Chain Triglyceride in Brain / Mental Clarity: Medium Chain Triglycerides Induce Mild Ketosis and May Improve Cognition in Alzheimer's Disease. A Systematic Review and Meta-Analysis of Human Studies. (Introduction/aim: The brain in Alzheimer's disease shows glucose hypometabolism but may utilize ketones for energy production... In this meta-analysis, we demonstrated that MCTs can induce mild ketosis and may improve cognition in patients with mild cognitive impairment and Alzheimer's disease. However, risk of bias of existing studies necessitates future trials. )

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