Do Jungmo, et al.
Korean journal of urology, 2013
Abstract
Purpose
Tribulus terrestris has been used as an aphrodisiac. However, little is known about the effects and mechanism of action of T. terrestris on penile erection. Therefore, the effect of a T. terrestris extract and the mechanism of action of the extract on relaxation of the corpus cavernosum (CC) were investigated. The erectogenic effects of an oral preparation of the extract were also assessed.
Materials and Methods
The relaxation effects and mechanism of action of the T. terrestris extract on rabbit CC were investigated in an organ bath. The intracavernous pressure (ICP) was calculated after oral administration of the extract for 1 month to evaluate whether the relaxation response of the CC shown in the organ bath occurred in vivo. Additionally, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) were measured in the CC by immunoassay. Smooth muscle relaxation was expressed as the percentage decrease in precontraction induced by phenylephrine. The ICP was also assessed in rats after oral administration of the extract for 1 month, and changes in concentrations of cGMP and cAMP were monitored.
Results
Concentration-dependent relaxation effects of the extract on the CC were detected in the organ bath study. Relaxation of the CC by the T. terrestris extract was inhibited in both an endothelium-removed group and an L-arginen methyl ester pretreatment group. The ICP measured after oral administration of the T. terrestris extract for 1 month was higher than that measured in the control group, and a significant increase in cAMP was observed in the T. terrestris extract group.
Conclusions
The T. terrestris extract induced concentration-dependent relaxation of the CC in an organ bath. The mechanism included a reaction involving the nitric oxide/nitric oxide synthase pathway and endothelium of the CC. Moreover, in an in vivo study, the T. terrestris extract showed a significant concentration-dependent increase in ICP. Accordingly, the T. terrestris extract may improve erectile function.
Keywords
Penile erection; Smooth muscle; Tribulus.
Conflict of interest statement
The authors have nothing to disclose.| PMID: | 23526694 |
|---|---|
| DOI: | 10.4111/kju.2013.54.3.183 |
| PMCID (Free PMC Article): | PMC3604572 |
| Category: | Male Aphrodisiac |
The best supplements with Tribulus Terrestris in Male Aphrodisiac category:
- Velofel - Male Enhancement System - Made with a blend of clinical strength ingredients, Velofel Male Enhancement is a male enhancement system that has been formulated to restore your sexual youth and performance and help you experience an intense, blissful & powerful sex life. It contains among others: Tribulus Terrestris.
- Spark Herbal Aphrodisiac CBD Capsules - 20 capsules/400 mg total CBD (Plants Not Pills) - Herbal aphrodisiac capsules with 20mg of organically-grown, THC-free CBD extract in each capsule. It contains among others: Tribulus Terrestris.
- TestoJack 200, 120 Veg Capsules (Now Foods) - NOW TestoJack 200 is a combination of natural herbal ingredients known to support a man's healthy sexual activity and overall vitality. It contains among others: Tribulus Terrestris.