Beta-glucan Recognition by the Innate Immune System.

Goodridge Helen S., Wolf Andrea J., Underhill David M.
Immunological reviews, 2009

Abstract

Beta-glucans are recognized by the innate immune system. This recognition plays important roles in host defense and presents specific opportunities for clinical modulation of the host immune response. Neutrophils, macrophages, and dendritic cells among others express several receptors capable of recognizing beta-glucan in its various forms. This review explores what is currently known about beta-glucan recognition and how this recognition stimulates immune responses. Special emphasis is placed on Dectin-1, as we know the most about how this key beta-glucan receptor translates recognition into intracellular signaling, stimulates cellular responses, and participates in orchestrating the adaptive immune response.

PMID:19594628
DOI:10.1111/j.1600-065X.2009.00793.x
PMCID (Free PMC Article):PMC6618291
Category:Immune

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