Reduction of Adipogenesis and Lipid Accumulation by Taraxacum Officinale (Dandelion) Extracts in 3T3L1 Adipocytes: An in Vitro Study.

González-Castejón Marta, et al.
Phytotherapy research, 2014

Abstract

In this in vitro study, we have investigated the ability of Taraxacum officinale (dandelion) to inhibit adipocyte differentiation and lipogenesis in 3T3-L1 preadipocytes. HPLC analysis of the three plant extracts used in this study-leaf and root extracts and a commercial root powder-identified caffeic and chlorogenic acids as the main phenolic constituents. Oil Red O staining and triglyceride levels analysis showed decreased lipid and triglyceride accumulation, respectively. Cytotoxicity was assessed with the MTT assay showing non-toxic effect among the concentrations tested. DNA microarray analysis showed that the extracts regulated the expression of a number of genes and long non-coding RNAs that play a major role in the control of adipogenesis. Taken together, our results indicate that the dandelion extracts used in this study may play a significant role during adipogenesis and lipid metabolism, and thus, supporting their therapeutic interest as potential candidates for the treatment of obesity.

Keywords

3 T3-L1 cells; adipogenesis; dandelion; differentiation; long noncoding RNAs; obesity; phytochemicals.

Copyright © 2013 John Wiley & Sons, Ltd.

PMID:23956107
DOI:10.1002/ptr.5059
Category:Weight Loss

The best supplements with Taraxacum Officinale in Weight Loss category:

  • KETO Core - You probably know what ketogenic diet is – that it consists of a major change of your eating habits. It contains among others: Taraxacum Officinale.
  • Water Out, Fluid Balance, 100 Veggie Caps (Now Foods) - NOW Water Out is a blend of complementary herbs and nutrients formulated to support healthy urinary tract function and proper bodily fluid balance. It contains among others: Taraxacum Officinale.
  • Bentolit drink mix - Bentolit - Instant slimming with a drink with volcanic clay. It contains among others: Taraxacum Officinale.

Articles similar to "Reduction of Adipogenesis and Lipid Accumulation by Taraxacum Officinale (Dandelion) Extracts in 3T3L1 Adipocytes: An in Vitro Study."

Previous article

Probiotic Bacteria Lactobacillus Acidophilus NCFM and Bifidobacterium Lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients With Functional Bowel Disorders: A Double-Blind Study.

Next article

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes.