Antifungal Activity of Magnolol and Honokiol.

Bang Kyu Ho, et al.
Archives of Pharmacal Research, 2000

Abstract

Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.

Articles similar to "Antifungal Activity of Magnolol and Honokiol."

• The properties of Honokiol: Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent. (Honokiol is a small-molecule polyphenol isolated from the genus Magnolia...)
• The properties of Magnolol: Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders. (Chinese herbs have been and still are widely used as important remedies in Oriental medicine...)
• The properties of Honokiol: Honokiol: A Promising Small Molecular Weight Natural Agent for the Growth Inhibition of Oral Squamous Cell Carcinoma Cells. (Honokiol (HNK) is a small organic molecule purified from magnolia species and has demonstrated anticancer activities in a variety of cancer cell lines; however, its effect on oral squamous cell carcinoma (OSCC) cells is unknown...)
• The properties of Magnolol: Honokiol and Magnolol Selectively Interact With GABAA Receptor Subtypes in Vitro. (Honokiol and magnolol have been identified as modulators of the GABAA receptors in vitro...)
• The properties of Magnolol: Therapeutic Applications of Compounds in the Magnolia Family. (The bark and/or seed cones of the Magnolia tree have been used in traditional herbal medicines in Korea, China and Japan...)

Previous article

Constituents From the Leaves of Phellodendron Amurense and Their Antioxidant Activity.

Next article

Safety Aspects of the Use of Quercetin as a Dietary Supplement.