Lee Wonhwa, Ku Sae-Kwang, Bae Jong-Sup
Archives of pharmacal research, 2013
Abstract
Endothelial protein C receptor (EPCR) plays an important role in the protein C anticoagulation pathway and in the cytoprotective pathway. Previously, EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Soluble EPCR levels are increased in patients with systemic inflammatory diseases. Recently, we reported that a new active compound, emodin-6-O-β-D-glucoside (EG) from Reynoutria japonica, has anti-inflammatory activities. However, little is known of the effects of EG on EPCR shedding. Here, we investigated this issue by monitoring the effects of EG on the phorbol-12-myristate 13-acetate (PMA) or the cecal ligation and puncture (CLP)-mediated EPCR shedding and its underlying mechanisms. Data showed that EG potently inhibited the PMA and CLP-induced EPCR shedding by suppressing TACE expression. Given these results, EG could be used as a candidate therapeutic for the treatment of vascular inflammatory diseases.
| PMID: | 23588681 |
|---|---|
| DOI: | 10.1007/s12272-013-0114-6 |
| Category: | Cardiovascular Support |
The best supplements with Reynoutria Japonica in Cardiovascular Support category:
- Natural Resveratrol, 200 mg, 120 Veg Capsules (Now Foods) - Resveratrol is a polyphenol naturally found in the skin of red grapes, certain berries, and other plants. It contains among others: Reynoutria Japonica.
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