Ramírez-Garza Sonia L., et al.
Nutrients, 2018
Abstract
The effect of resveratrol (RV) intake has been reviewed in several studies performed in humans with different health status. The purpose of this review is to summarize the results of clinical trials of the last decade, in which RV was determined in biological samples such as human plasma, urine, and feces. The topics covered include RV bioavailability, pharmacokinetics, effects on cardiovascular diseases, cognitive diseases, cancer, type 2 diabetes (T2D), oxidative stress, and inflammation states. The overview of the recent research reveals a clear tendency to identify RV in plasma, showing that its supplementation is safe. Furthermore, RV bioavailability depends on several factors such as dose, associated food matrix, or time of ingestion. Notably, enterohepatic recirculation of RV has been observed, and RV is largely excreted in the urine within the first four hours after consumption. Much of the research on RV in the last 10 years has focused on its effects on pathologies related to oxidative stress, inflammatory biomarkers, T2D, cardiovascular diseases, and neurological diseases.
Keywords
antioxidant; bioavailability; metabolic diseases; obesity.
PMID: | 30513922 |
---|---|
DOI: | 10.3390/nu10121892 |
PMCID (Free PMC Article): | PMC6317057 |
Category: | General properties of Resveratrol |
Articles similar to "Health Effects of Resveratrol: Results From Human Intervention Trials."
- The properties of Resveratrol: Resveratrol's Potential in the Adjunctive Management of Cardiovascular Disease, Obesity, Diabetes, Alzheimer Disease, and Cancer. (Resveratrol is a naturally occurring polyphenol that can be found in several human dietary sources, including red wine; many plants, especially grapes, berries, and nuts; and nutritional supplements...)
Previous article
Resveratrol and Vascular Function.