Yoshida M., et al.
European journal of clinical nutrition, 2006
Abstract
Objective
The purpose of this study was to determine whether supplements of plant sterols and/or glucomannan improve lipid profile and cholesterol biosynthesis in mildly hypercholesterolemic type II diabetic and non-diabetic subjects and to compare the response of these two subject groups to the treatments.
Design
A randomized, crossover study consisting of four phases of 21 days, with each phase separated by a 28-day washout.
Setting
The Mary Emily Clinical Nutrition Research Unit of McGill University.
Subjects
Eighteen non-diabetic individuals and 16 type II diabetic individuals aged 38-74 years.
Interventions
Subjects were supplemented with plant sterols (1.8 g/day), glucomannan (10 g/day), a combination of glucomannan and plant sterols, and a placebo, provided in the form of bars.
Results
Overall plasma cholesterol concentrations were lowered (P<0.05) after combination treatment (4.72+/-0.20 mmol/l) compared to control (5.47+/-0.18 mmol/l). Plasma low-density lipoprotein (LDL) cholesterol concentrations were decreased (P<0.05) after glucomannan (3.16+/-0.14 mmol/l) and combination treatments (2.95+/-0.16 mmol/l) compared to control (3.60+/-0.16 mmol/l). The results of lipid profiles did not differ between subject groups. Overall plasma lathosterol concentrations, an index of cholesterol biosynthesis, were lowered (P<0.05) after the combination treatment compared to the plant sterol treatment.
Conclusions
The results suggest that glucomannan and a combination of glucomannan and plant sterols substantially improves plasma LDL cholesterol concentrations.
Sponsorship
Forbes Medi-Tech Inc., Vancouver, British Columbia, Canada.
| PMID: | 16391591 |
|---|---|
| Category: | Diabetes / Blood Sugar |
Articles similar to "Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes."
- The significance of Amorphophallus Konjac for Diabetes / Blood Sugar: Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial. (OBJECTIVES: The present study was designed to evaluate effects of konjac glucomannan (KGM) supplement (3... The KGM supplement improved blood lipid levels by enhancing fecal excretion of neutral sterol and bile acid and alleviated the elevated glucose levels in diabetic subjects. KGM could be an adjunct for the treatment of hyperlipidemic diabetic subjects.)