Saitou Katsuyoshi, et al.
Nutrients, 2018
Abstract
Background
Chlorogenic acids (CGAs) have been attracting interest of late, owing to their health benefits. Here, we performed a randomized, double-blind, placebo-controlled trial to investigate whether CGAs improved cognitive function in humans.
Methods
Thirty-eight healthy participants were assigned to either the CGA group, which was given CGA-added beverage daily for 16 weeks, or the placebo group. Cognitive functions were assessed using the Japanese version of the CNS Vital Signs (Cognitrax).
Results
The CGA group showed significant increase in the Cognitrax domain scores for motor speed, psychomotor speed, and executive function compared with the placebo group, as well as an improvement in the shifting attention test scores. In blood analysis, the CGA group showed increased levels of apolipoprotein A1 and transthyretin, both of which are putative biomarkers for early-stage cognitive decline.
Conclusions
These results suggest that CGAs may improve some cognitive functions, which would help in the efficient performance of complex tasks.
Keywords
chlorogenic acid; cognitive functions; psychomotor speed
| PMID: | 30241302 |
|---|---|
| Category: | Brain / Mental Clarity |
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