Chumpitazi Bruno P., Kearns G. L., Shulman Robert J.
Alimentary pharmacology & therapeutics, 2018
Abstract
Background
Peppermint oil has been used for centuries as a treatment for gastrointestinal ailments. It has been shown to have several effects on gastrointestinal physiology relevant to clinical care and management.
Aim
To review the literature on peppermint oil regarding its metabolism, effects on gastrointestinal physiology, clinical use and efficacy, and safety.
Methods
We performed a PubMed literature search using the following terms individually or in combination: peppermint, peppermint oil, pharmacokinetics, menthol, oesophagus, stomach, small intestine, gallbladder, colon, transit, dyspepsia, nausea, abdominal pain, and irritable bowel syndrome. Full manuscripts evaluating peppermint oil that were published through 15 July 2017 were reviewed. When evaluating therapeutic indications, only randomised clinical trials were included. References from selected manuscripts were used if relevant.
Results
It appears that peppermint oil may have several mechanisms of action including: smooth muscle relaxation (via calcium channel blockade or direct enteric nervous system effects); visceral sensitivity modulation (via transient receptor potential cation channels); anti-microbial effects; anti-inflammatory activity; modulation of psychosocial distress. Peppermint oil has been found to affect oesophageal, gastric, small bowel, gall-bladder, and colonic physiology. It has been used to facilitate completion of colonoscopy and endoscopic retrograde cholangiopancreatography. Placebo controlled studies support its use in irritable bowel syndrome, functional dyspepsia, childhood functional abdominal pain, and post-operative nausea. Few adverse effects have been reported in peppermint oil trials.
Conclusion
Peppermint oil is a natural product which affects physiology throughout the gastrointestinal tract, has been used successfully for several clinical disorders, and appears to have a good safety profile.
© 2018 John Wiley & Sons Ltd.
| PMID: | 29372567 |
|---|---|
| Category: | Digestive Health |
The best supplements with Mentha X Piperita in Digestive Health category:
- KETO Core - You probably know what ketogenic diet is – that it consists of a major change of your eating habits. It contains among others: Mentha X Piperita.
- Detoxyn - Most of the human population are carriers of at least one parasite. It contains among others: Mentha X Piperita.
- RapidRelief, Gas & Bloating, 50 Capsules (Gaia Herbs) -
RapidRelief
You can maintain optimum health, when you give your body the right support. It contains among others: Mentha X Piperita. - Cleanse & Detox, Caffeine-Free, 16 Tea Bags, 1.13 oz (32 g) (Gaia Herbs) - Essential wellness from the inside out. It contains among others: Mentha X Piperita.
- Daily Digestive Enzymes with Prebiotics + Probiotics, 180 Vegetarian Capsules (Zenwise Health) - Zenwise Health Digestive Enzymes contain a specialized blend of plant-sourced Enzymes, Prebiotics, and Probiotics that encourage daily digestive health for men and women. It contains among others: Mentha X Piperita.
Articles similar to "Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders."
- The role of Mentha X Piperita in Digestive Health: The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. (Herbal remedies, particularly peppermint, have been reported to be helpful in controlling symptoms of irritable bowel syndrome (IBS)...)
- The impact of Mentha X Piperita on Digestive Health: Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial. (INTRODUCTION: The use of peppermint oil in treating the irritable bowel syndrome has been studied with variable results probably due to the presence of patients affected by small intestinal bacterial overgrowth, lactose intolerance or celiac disease that may have symptoms similar to irritable bowel syndrome... A 4 weeks treatment with peppermint oil improves abdominal symptoms in patients with irritable bowel syndrome.)
- The significance of Mentha X Piperita for Digestive Health: A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. ( Peppermint oil (PO) has shown promise as an IBS therapy, but previous trials have demonstrated variable efficacy and tolerability results... A novel PO formulation designed for sustained release in the small intestine is a safe, effective treatment capable of providing rapid relief of IBS symptoms. )
Previous article
Peppermint oil (Kligler, Chaudhary)