A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease.

Newport Mary T., et al.
Alzheimer's & Dementia, 2015

Abstract

Background

Providing ketone bodies to the brain can bypass metabolic blocks to glucose utilization and improve function in energy-starved neurons. For this, plasma ketones must be elevated well above the ≤ 0.2 mM default concentrations normally prevalent. Limitations of dietary methods currently used to produce therapeutic hyperketonemia have stimulated the search for better approaches.

Method

Described herein is a new way to produce therapeutic hyperketonemia, entailing prolonged oral administration of a potent ketogenic agent--ketone monoester (KME)--to a patient with Alzheimer's disease dementia and a pretreatment Mini-Mental State Examination score of 12.

Results

The patient improved markedly in mood, affect, self-care, and cognitive and daily activity performance. The KME was well tolerated throughout the 20-month treatment period. Cognitive performance tracked plasma beta-hydroxybutyrate concentrations, with noticeable improvements in conversation and interaction at the higher levels, compared with predose levels.

Conclusion

KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet. Published by Elsevier Inc.

Keywords

Brain insulin resistance; Fasting; Ketogenic diet; Ketone bodies; Ketone monoester; Medium-chain triglyceride; Pyruvate dehydrogenase; β-Hydroxybutyrate

The best supplements with 3-Hydroxybutyric Acid in Brain / Mental Clarity category:

• KETO Advanced Weight Loss (Exogenous Ketones) - Keto Advanced Weight Loss is a revolutionary breakthrough for people who want to lose weight using the benefits of KETOSIS. It contains among others: 3-Hydroxybutyric Acid.
• KETO BodyTone - A powerful fat burning ketone, BHB has been modified to produce a instant fat burning solution the natural way. It contains among others: 3-Hydroxybutyric Acid.

Articles similar to "A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease."

• The significance of 3-Hydroxybutyric Acid for Brain / Mental Clarity: Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. (Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the alleviation of depression and anxiety...)
• The role of 3-Hydroxybutyric Acid in Brain / Mental Clarity: Novel ketone diet enhances physical and cognitive performance. (Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP hydrolysis...)
• The impact of 3-Hydroxybutyric Acid on Brain / Mental Clarity: The ketogenic diet: metabolic influences on brain excitability and epilepsy. (A dietary therapy for pediatric epilepsy known as the ketogenic diet has seen a revival in its clinical use during the past decade...)
• The significance of 3-Hydroxybutyric Acid for Brain / Mental Clarity: Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. (Neuro-inflammation has been shown to play a critical role in the development of depression...)
• The role of 3-Hydroxybutyric Acid in Brain / Mental Clarity: Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. (Glucose is the brain's principal energy substrate...)
• The significance of 3-Hydroxybutyric Acid for Brain / Mental Clarity: β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms. (β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel...)

Previous article

Effects of beta-hydroxybutyrate on cognition in memory-impaired adults.

Next article

Vitamins K1 and K2: the emerging group of vitamins required for human health.