Cavaleri Franco, Bashar Emran
Journal of nutrition and metabolism, 2018
Abstract
The low-carbohydrate high-fat diet (LCHFD), also known as the ketogenic diet, has cycled in and out of popularity for decades as a therapeutic program to treat metabolic syndrome, weight mismanagement, and drug-resistant disorders as complex as epilepsy, cancer, dementia, and depression. Despite the benefits of this diet, health care professionals still question its safety due to the elevated serum ketones it induces and the limited dietary fiber. To compound the controversy, patient compliance with the program is poor due to the restrictive nature of the diet and symptoms related to energy deficit and gastrointestinal adversity during the introductory and energy substrate transition phase of the diet. The studies presented here demonstrate safety and efficacy of the diet including the scientific support and rationale for the administration of exogenous ketone bodies and ketone sources as a complement to the restrictive dietary protocol or as an alternative to the diet. This review also highlights the synergy provided by exogenous ketone, β-hydroxybutyrate (BHB), accompanied by the short chain fatty acid, butyrate (BA) in the context of cellular and physiological outcomes. More work is needed to unveil the molecular mechanisms by which this program provides health benefits.
PMID: | 29805804 |
---|---|
PMCID (Free PMC Article): | PMC5902005 |
DOI: | 10.1155/2018/7195760 |
Category: | Ketogenic diet |
The best supplements with 3-Hydroxybutyric Acid in Ketogenic diet category:
- Keto Trim - Keto Trim is a formula that provides you with ready-to-use ketone bodies to jump-start your keto weight loss journey. It contains among others: 3-Hydroxybutyric Acid.
- Simple Keto Boost - Simple Keto Boost contains Beta-hydroxybutyrate. It contains among others: 3-Hydroxybutyric Acid.
- KETO Complete 100% Pure BHB - A recent study published by the Diabetes, Obesity, and Metabolism Journal found that KETO Complete supported burning fat for energy instead of carbohydrates greatly increasing weight loss and energy. It contains among others: 3-Hydroxybutyric Acid.
- Keto Extreme Fat Burner - A powerful fat burning ketone, BHB has been modified to produce an instant fat burning solution the natural way. It contains among others: 3-Hydroxybutyric Acid.
- KETO Advanced Weight Loss (Exogenous Ketones) - Keto Advanced Weight Loss is a revolutionary breakthrough for people who want to lose weight using the benefits of KETOSIS. It contains among others: 3-Hydroxybutyric Acid.
- KETO BodyTone - A powerful fat burning ketone, BHB has been modified to produce a instant fat burning solution the natural way. It contains among others: 3-Hydroxybutyric Acid.
Articles similar to "Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health."
- The role of 3-Hydroxybutyric Acid in Ketogenic diet: The use of nutritional supplements to induce ketosis and reduce symptoms associated with keto-induction: a narrative review. ( Adaptation to a ketogenic diet (keto-induction) can cause unpleasant symptoms, and this can reduce tolerability of the diet... There is a clear ketogenic effect of supplemental MCTs; however, it is unclear whether they independently improve time to NK and reduce symptoms of keto-induction. There is limited research on the potential for other supplements to improve time to NK and reduce symptoms of keto-induction. Few studies have specifically evaluated symptoms and adverse effects of a ketogenic diet during the induction phase. Those that have typically were not designed to evaluate these variables as primary outcomes, and thus, more research is required to elucidate the role that supplementation might play in encouraging ketogenesis, improve time to NK, and reduce symptoms associated with keto-induction. )
- The impact of 3-Hydroxybutyric Acid on Ketogenic diet: On the Metabolism of Exogenous Ketones in Humans. (Background and aims: Currently there is considerable interest in ketone metabolism owing to recently reported benefits of ketosis for human health... We conclude that exogenous ketone drinks are a practical, efficacious way to achieve ketosis.)
- The significance of 3-Hydroxybutyric Acid for Ketogenic diet: Ketone body metabolism in lean and obese women. (Previous studies have demonstrated decreases in whole-body and muscle fat oxidation in obese individuals... We conclude that exogenous ketone drinks are a practical, efficacious way to achieve ketosis.)
- The role of 3-Hydroxybutyric Acid in Ketogenic diet: Obese men have elevated plasma levels of estrone sulfate. (The 24 h mean plasma concentrations of estrone sulfate (ES) were measured in 27 healthy obese and nonobese men (BMI: 21... We conclude that exogenous ketone drinks are a practical, efficacious way to achieve ketosis.)
- The impact of 3-Hydroxybutyric Acid on Ketogenic diet: Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects. (CONTEXT: Increased plasma free fatty acid (FFA) concentrations may be in part responsible for the increased levels of ceramide in skeletal muscle of obese subjects... Short-term manipulation of plasma FFAs has no effect on ceramide and glucosylceramide concentrations in skeletal muscle from lean and obese subjects.)
- The significance of 3-Hydroxybutyric Acid for Ketogenic diet: Plasma B6 vitamer and plasma and urinary 4-pyridoxic acid concentrations of middle-aged obese black women. (Plasma B6 vitamer and plasma and urinary 4-pyridoxic acid (4-PA) concentrations of fifteen middle-aged obese black women were determined by high-performance liquid chromatography (HPLC)... Short-term manipulation of plasma FFAs has no effect on ceramide and glucosylceramide concentrations in skeletal muscle from lean and obese subjects.)
- The role of 3-Hydroxybutyric Acid in Ketogenic diet: Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population. (CONTEXT: Gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after a specific diet... Our results suggest that long-term consumption of the Med and LFHCC diets exerts a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and F. prausnitzii, respectively. TRIAL REGISTRATION: ClinicalTrials: NCT00924937.)
- The impact of 3-Hydroxybutyric Acid on Ketogenic diet: The modified Atkins diet. (In 2003, a case series was published describing the benefits of a less restrictive ketogenic diet (KD) started as an outpatient without a fast and without any restrictions on calories, fluids, or protein... Our results suggest that long-term consumption of the Med and LFHCC diets exerts a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and F. prausnitzii, respectively. TRIAL REGISTRATION: ClinicalTrials: NCT00924937.)