Virtanen Jyrki K., Tuomainen Tomi-Pekka, Voutilainen Sari
European journal of nutrition, 2020
Abstract
Purpose
To investigate associations of total dietary choline intake and its major dietary form, phosphatidylcholine, with type 2 diabetes risk.
Methods
We included 2332 men aged 42-60 years at baseline in 1984-1989 from the Kuopio Ischaemic Heart Disease Risk Factor Study in eastern Finland. Dietary intakes were assessed with 4-d food recording at baseline. Type 2 diabetes diagnosis was based on self-administered questionnaires, fasting and 2-h oral glucose tolerance test blood glucose measurements, or by record linkage to national health registries. Multivariable-adjusted Cox proportional hazards regression models were used for statistical analysis.
Results
During the mean 19.3-year follow-up, 432 men had type 2 diabetes diagnosis. After multivariable adjustments, those in the highest vs. lowest choline intake quartile had 25% (95% CI 2-43%) lower relative risk (P trend across quartiles = 0.02) and those in the highest vs. lowest phosphatidylcholine quartile had 41% (95% CI 22-55%) lower relative risk (P trend < 0.001) of type 2 diabetes.
Conclusions
Higher choline intake, especially phosphatidylcholine, was associated with lower type 2 diabetes risk among men.
Keywords
Choline; Diet; Phosphatidylcholine; Population study; Prospective study; Type 2 diabetes.
Conflict of interest statement
On behalf of all authors, the corresponding author states that there is no conflict of interest.| PMID: | 32198672 |
|---|---|
| PMCID (Free PMC Article): | PMC7669791 |
| DOI: | 10.1007/s00394-020-02223-2 |
| Category: | Diabetes / Blood Sugar |
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