Berberine and Its Role in Chronic Disease.

Cicero Arrigo F. G., Baggioni Alessandra
Anti-inflammatory Nutraceuticals and Chronic Diseases, 2016

Abstract

Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis [e.g. Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Berberis aristata (tree turmeric)], Hydrastis canadensis (goldenseal), Xanthorhiza simplicissima (yellowroot), Phellodendron amurense [2] (Amur corktree), Coptis chinensis (Chinese goldthread), Tinospora cordifolia, Argemone mexicana (prickly poppy) and Eschscholzia californica (Californian poppy). In vitro it exerts significant anti-inflammatory and antioxidant activities. In animal models berberine has neuroprotective and cardiovascular protective effects. In humans, its lipid-lowering and insulin-resistance improving actions have clearly been demonstrated in numerous randomized clinical trials. Moreover, preliminary clinical evidence suggest the ability of berberine to reduce endothelial inflammation improving vascular health, even in patients already affected by cardiovascular diseases. Altogether the available evidences suggest a possible application of berberine use in the management of chronic cardiometabolic disorders.

Keywords

Anti-inflammatory; Antioxidant; Berberine; Cardiovascular disease; Depression; Type 2 diabetes.

The best supplements with Berberine, Berberis Vulgaris, Berberis Aristata, Hydrastis Canadensis, Phellodendron Amurense, Eschscholzia Californica or Coptis Chinensis in Digestive Health category:

• Detoxyn - Most of the human population are carriers of at least one parasite. It contains among others: Berberine, Hydrastis Canadensis.
• Parasite Complex - Vitabase Parasite Complex contains natural herbs such as garlic, black walnut, wood betony, Pau D Arco, butternut bark that are traditionally used to help rid the body of parasites. It contains among others: Hydrastis Canadensis, Coptis Chinensis.

Articles similar to "Berberine and Its Role in Chronic Disease."

• The significance of Berberine for Digestive Health: Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. (The increased incidence of metabolic diseases (e...)
• The impact of Berberine on Digestive Health: Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders. (Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids found in such plants as gender Berberis...)
• The significance of Berberine for Digestive Health: Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. (The antibacterial activity of extract and isolated major alkaloids (berberine, beta-hydrastine, canadine and canadaline) of Hydrastis canadensis L...)
• The properties of Hydrastis Canadensis: Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues. (Goldenseal (Hydrastis canadensis L...)
• The properties of Coptis Chinensis: Berberine and Coptidis Rhizoma as Novel Antineoplastic Agents: A Review of Traditional Use and Biomedical Investigations. (Ethnopharmacological relevance: Coptidis rhizoma (huanglian) and its major component, berberine, have drawn extensive attention toward their antineoplastic effects in the recent years... The modern evidences of treating cancer with huanglian and berberine have a strong linkage with traditional concept and rules of using huanglian in CM practice. As anticancer candidates with low toxicity, berberine and its altered structure, as well as huanglian and its formulae, will attract scientists to pursue the potential anticancer effects and the mechanisms by using technologies of genomics, proteomics and other advanced approaches. On the other hand, relatively few in vivo studies have been conducted on anticancer effects of huanglian and berberine. The clinical application of berberine or huanglian as novel cancer therapeutic agents requires in vivo validations and further investigations of their anticancer mechanisms.)

Previous article

Human pancreatic digestive enzymes.

Next article

Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders.