Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression.

Hen-Shoval D., et al.
Behavioural brain research, 2018

Abstract

Background and

Purpose

Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar-Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key

Results

1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.

Keywords

Cannabidiolic acid methyl ester; Flinders Sensitive Line (FSL); Forced swim test (FST); Genetic animal models of depression; Major depression disorder (MDD); Wistar–Kyoto (WKY).

Copyright © 2018 Elsevier B.V. All rights reserved.

PMID:29860002
DOI:10.1016/j.bbr.2018.05.027
Category:Brain / Mental Clarity

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