Seida Ahmed, El-Hefnawy Hala, Abou-Hussein Dina, Alzahraa Mokhtar Fatma, Abdel-Naim Ashraf
Pakistan Journal of Pharmaceutical Sciences, 2015
Abstract
Medicago sativa L. (Alfalfa) is traditionally used to treat diabetes. This study was designed to investigate the potential antihyperlipidemic and antihyperglycemic activity of M. sativa sprouts in streptozotocin (STZ) induced diabetes via i.p. injection of 55 mg/kg of STZ. Experimental animals were divided into the following groups: GP1 (normal), GP2 (STZ-hyperlipidemic), GP3 (rouvastatin), GP4 (metformin), GP 5-9 (diabetic treated with methanolic, petroleum ether, chloroform, ethyl acetate and butanol extracts). The administration of the total methanolic extract (500 mg/kg), the petroleum ether (32.5mg) and butanol fractions (60 mg) for 4 weeks significantly decreased (p<0.05) triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL) and very low density lipoproteins (VLDL) in comparison to rouvastatin. Petroleum ether fraction proved to exhibit the best activity as antihyperlipidemic agent (12.23%). On the other hand, ethyl acetate fraction retained the best activity (vs. metformin) as antihyperglycemic agent. Histopathological evidences on liver, pancreas and spleen were in agreement with the above mentioned results. Purification, characterization, and identification of isolated compounds from the active fractions afforded 9 compounds: β-sitosterol and stigmasterol from the petroleum ether fraction; 10-hydroxy-coumestrol, apigenin, genistein, p-hydroxy-benzoic-acid, 7, 4'- dihydroxyflavone, quercetin-3-glucoside and sissotrin from the ethyl acetate fraction.
| PMID: | 26639479 |
|---|---|
| Category: | Diabetes / Blood Sugar |
| Category: | Energy |
The best supplements with Medicago Sativa in Energy category:
- Thyrolin - Thyrolin, thanks to its advanced composition, effectively cares for the proper functioning of the thyroid gland and the proper production of its hormones. It contains among others: Medicago Sativa.
Articles similar to "Evaluation of Medicago sativa L. sprouts as antihyperlipidemic and antihyperglycemic agent."
- The role of Medicago Sativa in Diabetes / Blood Sugar: Alfalfa seeds: effects on cholesterol metabolism. (Plasma cholesterol concentrations were reduced in 3 human volunteers during ingestion of diets containing alfalfa seeds (AS) for 3 weeks...)
Previous article
Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda.