Paul Ligi, Ueland Per Magne, Selhub Jacob
Nutrition reviews, 2013
Abstract
A variety of inflammatory disease conditions have been found to be associated with low levels of plasma pyridoxal 5'-phosphate (PLP), the active form of vitamin B6 , without any indication of a lower dietary intake of vitamin B6 , excessive catabolism of the vitamin, or congenital defects in its metabolism. The present review was conducted to examine the existing literature in this regard. Current evidence suggests that the inverse association between plasma PLP and inflammation may be the result of mobilization of this coenzyme to the site of inflammation, for use by the PLP-dependent enzymes of the kynurenine pathway of tryptophan degradation, metabolism of the immunomodulatory sphingolipids, ceramide and sphingosine 1-phosphate, and for serine hydroxymethylase for immune cell proliferation.
© 2013 International Life Sciences Institute.
| PMID: | 23550784 |
|---|---|
| DOI: | 10.1111/nure.12014 |
| Category: | Immune |
The best supplements with Pyridoxine or Pyridoxal Phosphate in Immune category:
- Melatonin, 3 mg, 180 Lozenges (Now Foods) - Melatonin is a potent free radical scavenger naturally produced in the pineal gland. It contains among others: Pyridoxine.
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