Anti-HIV Cyclotides From the Chinese Medicinal Herb Viola Yedoensis.

Wang Conan K. L., et al.
Journal of natural products, 2008

Abstract

Cyclotides are macrocyclic plant peptides characterized by a knotted arrangement of three disulfide bonds. They display a range of interesting bioactivities, including anti-HIV and insecticidal activities. More than 100 different cyclotides have been isolated from two phylogenetically distant plant families, the Rubiaceae and Violaceae. In this study we have characterized the cyclotides from Viola yedoensis, an important Chinese herb from the Violaceae family that has been reported to contain potential anti-HIV agents. From V. yedoensis five new and three known cyclotides were identified and shown to have anti-HIV activity. The most active of these is cycloviolacin Y5, which is one of the most potent of all cyclotides tested so far using in vitro XTT-based anti-HIV assays. Cycloviolacin Y5 is the most hydrophobic of the cyclotides from V. yedoensis. We show that there is a positive correlation between the hydrophobicity and the anti-HIV activity of the new cyclotides and that this trend tracks with their ability to disrupt membranes, as judged from hemolytic assays on human erythrocytes.

PMID:18081258
PMCID (Free PMC Article):PMC6327322
DOI:10.1021/np070393g
Category:Immune

Articles similar to "Anti-HIV Cyclotides From the Chinese Medicinal Herb Viola Yedoensis."

Previous article

Antibacterial Activity of the Chinese Traditional Medicine, Zi Hua Di Ding.

Next article

Anti-inflammatory Activity of Arctigenin From Forsythiae Fructus.