Isatisine A, a Novel Alkaloid With an Unprecedented Skeleton From Leaves of Isatis Indigotica.

Liu Ji-Feng, et al.
Organic letters, 2007

Abstract

9alpha,13alpha-Dihydroxylisopropylidenylisatisine A (1), which was derived from isatisine A (2) and possessed an unprecedented fused pentacyclic skeleton, was isolated from the leaves of Isatis indigotica Fort. The structure and relative configuration were elucidated on the basis of extensive NMR analyses and finally determined by single-crystal X-ray diffraction. Compound 1 showed moderate anti-HIV-1 activity with EC50 = 37.8 microM and SI = 7.98.

Articles similar to "Isatisine A, a Novel Alkaloid With an Unprecedented Skeleton From Leaves of Isatis Indigotica."

• The significance of Isatis Tinctoria for Immune: Anti-inflammatory and Antimicrobial Effects of Heat-Clearing Chinese Herbs: A Current Review. (Inflammation is a normal immune response; but if the body's regulation of inflammation is dysfunctional, then it will have an adverse effect on the body...)
• The impact of Isatis Tinctoria on Immune: Anti-SARS Coronavirus 3C-like Protease Effects of Isatis Indigotica Root and Plant-Derived Phenolic Compounds. (The 3C-like protease (3CLpro) of SARS-coronavirus mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, becoming an important target for the drug development...)
• The significance of Isatis Tinctoria for Immune: The Cytotoxicity to Leukemia Cells and Antiviral Effects of Isatis Indigotica Extracts on Pseudorabies Virus. (Aim of the study: Isatis indigotica (I... Isatis indigotica posses a valuable virucidal effect in disease control of pseudorabies virus infection in swine.)
• The role of Isatis Tinctoria in Immune: Effects of Herbal Medicinal Formulas on Suppressing Viral Replication and Modulating Immune Responses. (The Chinese medicinal herbs Radix Isatidis and Viola yedoensis Makino have been suggested to possess antiviral activity... Isatis indigotica posses a valuable virucidal effect in disease control of pseudorabies virus infection in swine.)
• The impact of Isatis Tinctoria on Immune: The Anti-Inflammatory Effects of a Methanolic Extract From Radix Isatidis in Murine Macrophages and Mice. (Radix Isatidis is the dried root of the plant Isatidis indigotica Fort (family Cruciferae) and traditionally used as an anti-viral, anti-bacterial, anti-endotoxic, and immune regulatory agent in the folk medicine of Korea and China... Isatis indigotica posses a valuable virucidal effect in disease control of pseudorabies virus infection in swine.)
• The significance of Isatis Tinctoria for Immune: Thermochemical Studies on the Quantity-Antibacterial Effect Relationship of Four Organic Acids From Radix Isatidis on Escherichia Coli Growth. (In this report, we have investigated the inhibitory action of four organic acids from Radix Isatidis on Escherichia coli growth was investigated at 37 degrees C by using a microcalorimeter... Isatis indigotica posses a valuable virucidal effect in disease control of pseudorabies virus infection in swine.)

Previous article

The Effect of Medicinal Plants Used in Chinese Folk Medicine on RANTES Secretion by Virus-Infected Human Epithelial Cells.

Next article

Chemical Fingerprinting of Isatis Indigotica Root by RP-HPLC and Hierarchical Clustering Analysis.