What are the properties of Red Clover in supplements?

Red Clover - References & External links

Red Clover (Trifolium Pratense)

The references to scientific articles about Red Clover are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

• The general properties of Red Clover:
  • GOUNDEN, Thaveshan; MOODLEY, Roshila; JONNALAGADDA, Sreekantha B. Elemental analysis and nutritional value of edible Trifolium (clover) species. Journal of Environmental Science and Health, Part B, 2018, 53.8: 487-492. PMID:29708825
  • LUTTER, Stefanie; et al. The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover. Archives of toxicology, 2014, 88.2: 309-321. PMID:23982890
  • DOBRUCKA, Renata; DłUGASZEWSKA, Jolanta. Biosynthesis and antibacterial activity of ZnO nanoparticles using Trifolium pratense flower extract. Saudi journal of biological sciences, 2016, 23.4: 517-523. PMID:27298586
• The properties of Red Clover for Your Beauty:
  • LIPOVAC, Markus; et al. Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. Obstetrics and gynecology international, 2011, 2011: . PMID:22135679
    CONCLUSION: RCE supplementation exerted a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women.
• The properties of Red Clover against Menopause syndrome:
  RCE (Red Clover Extract) supplementation exerts a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women.
  • MYERS, Stephen P.; VIGAR, Vanessa. Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine, 2017, 24: 141-147. PMID:28160855
    CONCLUSION: There is evidence for a statistical and clinically significant benefit for using a specific standardised extract of red clover isoflavones (Promensil) at 80mg/day for treating hot flushes in menopausal women across the 3 studies included in the meta-analysis. The preparation was safe over the short-term duration of the studies (3 months).
  • BUDRYN, Grażyna; et al. Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling. Food chemistry, 2018, 245: 324-336. PMID:29287378
  • LAMBERT, Max Norman Tandrup; et al. Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms. PloS one, 2017, 12.6: e0176590. PMID:28591133
    CONCLUSION: Results suggest that moderate doses of RCE were more effective and superior to placebo in reducing physiological and self-reported VMS. Findings support that objective physiological symptom assessment methods should be used together with self-report measures in future studies on menopausal VMS. TRIAL REGISTRATION: ClinicalTrials.gov NCT02028702.
  • LUíS, Â; DOMINGUES, F.; PEREIRA, L. Effects of red clover on perimenopausal and postmenopausal women's blood lipid profile: A meta-analysis. Climacteric, 2018, 21.5: 446-453. PMID:30269660
  • SHAKERI, F.; et al. Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Climacteric, 2015, 18.4: 568-573. PMID:25581426
    CONCLUSION: These results indicated that, compared to placebo, dried leaves of red clover were more effective in reducing the severity of menopausal symptoms in postmenopausal women.
  • LIPOVAC, Markus; et al. Red clover isoflavone metabolite bioavailability is decreased after fructooligosaccharide supplementation. Fitoterapia, 2015, 105: 93-101. PMID:26073948
    CONCLUSION: This study is the first to provide detailed data on RCI bioavailability in humans and determine no influence of FOS yet a trend toward increased equol production. More research is warranted involving a greater sample size.
  • CHEN, M. N.; LIN, C. C.; LIU, C. F. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric, 2015, 18.2: 260-269. PMID:25263312
    CONCLUSION: Phytoestrogens appear to reduce the frequency of hot flushes in menopausal women, without serious side-effects.
  • GHAZANFARPOUR, Masumeh; et al. Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis. Avicenna journal of phytomedicine, 2015, 5.6: 498. PMID:26693407
    CONCLUSION: Red clover had a positive effect of alleviating hot flash in menopausal women. Our data, however, suggested very slight changes in FSH, LH, testosterone, and SHBG and significant effect in estrogen status by red clover consumption. However, the interpretation of results of the current study is limited due to methodological flaws of the included studies, menopause status, and large heterogeneity among them. Further trials are still needed to confirm the current finding.
• The properties of Red Clover - antioxidative impact:
  • KAURINOVIC, Biljana; et al. Antioxidant profile of Trifolium pratense L. Molecules, 2012, 17.9: 11156-11172. PMID:22990457