What are the properties of Phosphatidylserine in supplements?

The Supplements with PhosphatidylserineThe Supplements with Phosphatidylserine

The properties of Phosphatidylserine

Phosphatidylserine (C13H24NO10P) – Speaking of ‘other’ omega-3 fatty acids, phosphatidylserine (PS) is one of them. It works with DHA to perform many essential brain functions and is linked to improved concentration, mood and short-term memory. PS appears to help function of neurotransmitters, enhance glucose absorption and simply ‘turn back the clock’ on the aging brain.
Phosphatidylserine is indicated in the treatment of cognitive impairment, including Alzheimer's disease, age-associated memory impairment and some non-Alzheimer's dementias.

Phosphatidylserine is an important chemical with widespread functions in the body. It's key in the maintenance of cellular functions, especially within the brain. There's a decent amount of literature showing its positive effects in elderly individuals both with and without cognition and memory impairments.
Phosphatidylserine has also been shown to improve cognitive function before a bout of exercise. By supplementing with phosphatidylserine, individuals may potentially be able to obtain better results from exercise (by staying focused and alert) and at the same time improve mood and mental function.
And for all of you struggling through calculus, supplementing with phosphatidylserine has been shown to increase cognitive function during math problems (faster times completing calculations and increased number of correct answers).
As mentioned above, phosphatidylserine can also blunt the cortisol response following aerobic activity. So, not only will you be able to answer the question, “What is the square root of 2 to the negative 9 plus 3 power?” without the use of a calculator, you'll be able to maintain your muscle mass! More about Phosphatidylserine on Stress Management Basics: Phosphatidylserine.


The supplements containing Phosphatidylserine

Brain PillBrain Pill

English version

Brain Pill contains Phosphatidylserine.
„An amazing new product that supports your brain health and has the potential to change your life returning laser-sharp mental clarity” - Dr Dave David, a surgeon and physician for more than 37 years. „I recommend Brain Pill to anyone who values sharp thinking, laser focus and is committed...
Vitabase - Brain SupportVitabase - Brain Support

English version

Vitabase – Brain Support contains Phosphatidylserine.
Vitabase - Brain Support is a combination of six different herbs and ingredients designed to help support brain function. Brain Support combines an extremely high quality ginkgo biloba extract, phosphatidyl serine, acetyl L-carnitine, DHA powder, choline and inositol.

If you know of any other quality supplement that has not been yet classified by us, please contact us and we will gladly consider adding it to our catalogue.

Phosphatidylserine - References & External links

Phosphatidylserine (Phosphatidyl-L-serine)

TBS Ingredient ID (TBSI ID):
NameMolecular Formula:
Phosphatidyl-L-Serine, Ptd-L-Ser, Distearoylphosphatidylserine
Classification TypeIdentifier
PubChem CID:
U.S. National Library of Medicine (PubChem)
InChI Key:
International Chemical Identifier hash (InChIKey) computed from chemical structure using the International Union of Pure and Applied Chemistry (IUPAC) standard
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)
The National Institute of Standards and Technology (NIST)
United States National Library of Medicine - TOXNET (Toxicology Data Network).
Chemical Entities of Biological Interest (ChEBI) - Dictionary of molecular entities focused on "small" chemical compounds. ChEBI is part of the EMBL-European Bioinformatics Institute.

The references to scientific articles about Phosphatidylserine are not meant to imply that any products treat, cure, or diagnose any disease or human condition. We encourage our audience to do their own research beyond the resources we have provided so your decision is as educated as possible.

  • The properties of Phosphatidylserine boosting Brain / Mental Clarity:
    • GLADE, Michael J.; SMITH, K. Nutrition, 2015, 31.6: 781-786. PMID:
      CONCLUSION: Phosphatidylserine is required for healthy nerve cell membranes and myelin. Aging of the human brain is associated with biochemical alterations and structural deterioration that impair neurotransmission. Exogenous PS (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes.
    • CROOK, Thomas H.; TINKLENBERG, J.; YESAVAGE, J.; PETRIE, W.; NUNZI, M. G.; MASSARI, D. C. Neurology, 1991, 41.5: 644-649. PMID:
    • KIM, Hee-Yong; HUANG, Bill X.; SPECTOR, Arthur A. Progress in lipid research, 2014, 56: 1-18. PMID:
    • CENACCHI, Teresa; BERTOLDIN, T.; FARINA, C.; FIORI, M. G.; CREPALDI, G. Aging Clinical and Experimental Research, 1993, 5.2: 123-133. PMID:
    • MAGGIONI, M.; PICOTTI, G. B.; BONDIOLOTTI, G. P.; PANERAI, A.; CENACCHI, T.; NOBILE, P.; BRAMBILLA, F. Acta Psychiatrica Scandinavica, 1990, 81.3: 265-270. PMID:
    • MCDANIEL, Mark A.; MAIER, Steven F.; EINSTEIN, Gilles O. Nutrition, 2003, 19.11-12: 957-975. PMID:
      CONCLUSIONS: In sum, for most of the "brain-specific" nutrients we review, some mildly suggestive effects have been found in preliminary controlled studies using standard psychometric memory assessments or more general tests designed to reveal cognitive impairment. We suggest that future evaluations of the possible memory benefits of these supplements might fruitfully focus on memory processes rather than on memory tests per se.
  • The properties of Phosphatidylserine for people active in sport: