What are the properties of Papain in supplements?

The properties of Papain

Papain, also known as papaya proteinase I, is a cysteine protease enzyme present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis).
It is also used as an ingredient in various enzymatic debriding preparations, notably Accuzyme. These are used in the care of some chronic wounds to clean up dead tissue.

Papain is the main ingredient of Papacarie, a gel used for chemomechanical dental caries removal. It does not require drilling and does not interfere in the bond strength of restorative materials to dentin.

The supplements containing Papain

If you know of any other quality supplement that has not been yet classified by us, please contact us and we will gladly consider adding it to our catalogue.


TBS Ingredient ID (TBSI ID):
Classification TypeIdentifier
A proprietary registry number assigned by the Chemical Abstracts Service (CAS) division of the American Chemical Society (ACS)
The National Institute of Standards and Technology (NIST)
United States National Library of Medicine - TOXNET (Toxicology Data Network).
EC Number:
A seven-digit regulatory identifier currently assigned by the European Chemicals Agency (ECHA) known as a European Community (EC) number
IntEnz (Integrated relational Enzyme database) contains data on enzymes organized by enzyme EC number and is the official version of the Enzyme Nomenclature system developed by the International Union of Biochemistry and Molecular Biology (IUBMB)
BRENDA (The Comprehensive Enzyme Information System) is an information system representing one of the most comprehensive enzyme repositories
ExPASy - SIB (Swiss Institute of Bioinformatics) Bioinformatics Resource Portal
The MetaCyc database is one of the largest metabolic pathways and enzymes databases currently available. The data in the database is manually curated from the scientific literature, and covers all domains of life
PRIAM enzyme-specific profiles is a method for the automatic detection of likely enzymes in protein sequences. PRIAM uses position-specific scoring matrices (also known as profiles) automatically generated for each enzyme entry
Kyoto Encyclopedia of Genes and Genomes (KEGG)
The RSCB PDB (Protein Data Bank) - Biological Macromolecular Structures Enabling Breakthroughs in Research and Education
Protein Data Bank in Europe (PDBe). Bringing Structure to Biology
EC-PDB database contains the known enzyme structures that have been deposited in the Protein Data Bank (PDB).