Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity.

Vasques Carlos A. R., Rossetto Simone, Halmenschlager Graziele, Linden Rafael, Heckler Eliane, Poblador Fernandez Maria S., Lancho Alonso José L.
Phytotherapy Research, 2008

Abstract

Hydroxycitric acid (HCA), the main compound of Garcinia cambogia extract, is a competitive blocker of ATP‐citrate‐lyase, presenting a potential inhibition of fatty acid biosynthesis.

Glucomannan fibers, abundant in Amorphophallus konjac, seem to reduce the absorption kinetics of dietary fat. Therefore, the aim of this double‐blind randomized study was to evaluate the pharmacotherapeutic efficacy of standardized extracts of G. cambogia (52.4% HCA) plus A. konjac (94.9% glucomannan) in the treatment of obesity. Fifty‐eight obese subjects (BMI 30.0–39.9 kg/m2) were assigned to the placebo group (n = 26) or the treatment group (n = 32); no dietary restrictions were applied. Over a 12‐week period, subjects were given daily doses of either Garcinia (2.4 g) plus Konjac (1.5 g) or placebo prior to their main meals (3 times/day). Before the start of treatment, and every 4 weeks thereafter, the following were recorded: height, weight, circumferences and body composition, resting energy expenditure (REE), lipid profile and glucose levels.

The treatment had no significant effect on anthropometric parameters, REE, triglycerides or glucose levels. However, a significant reduction was observed in total cholesterol (−32.0 ± 35.1 mg/dL) and LDL‐c levels (−28.7 ± 32.7 mg/dL) in the treated group, the final levels being significantly lower than those of the placebo group (p = 0.008 and p = 0.020, respectively). The results obtained suggest that the treatment had a significant hypocholesterolemic effect, without influencing the anthropometric or calorimetric parameters tested. Copyright © 2008 John Wiley & Sons, Ltd.

PMID:18729243
DOI:10.1002/ptr.2323
Category:Weight Loss

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